First published in 1984. Routledge is an imprint of Taylor & Francis, an informa company.

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

"L'auteur discute ici certaines grandes questions qui préoccupent aujourd'hui les philosophes de l'histoire en Grande-Bretagne et aux Etats-Unis. Dans chaque cas, il analyse le point de vue d'un philosophe ou d'un historien bien connu: R. G. Collingwood, Charles Beard, J. W. N. Watkins, A. J. P. Taylor et O. Spengler.

Lycan not only uses the numerous arguments against materialism, and functionalist theories of mind in particular, to gain a more detailed positive view of the ..

The importance of the Tree of Life when looked at from its negative side will give the reader new perspective of the spiritual path. Ignorance of universal law can mean that when you think you are doing "good", you may actually be doing "evil". Consciousness is the key. This is an important book for students on any path.

Toward theory a homuncular of believing For years and years, philosophers took thoughts and beliefs to be modifications of incorporeal Cartesian egos. ...

In this book, William Lycan reviews the diverse philosophical views on consciousness--including those of Kripke, Block, Campbell, Sellars, and Casteneda--and ..

This book contends that insufficient attention has been paid to the syntax of conditionals, as investigated by linguists.

_Philosophy of Language_ introduces the student to the main issues and theories in twentieth-century philosophy of language. Topics are structured in three parts in the book. Part I, Reference and Referring Expressions, includes topics such as Russell's Theory of Desciptions, Donnellan's distinction, problems of anaphora, the description theory of proper names, Searle's cluster theory, and the causal-historical theory. Part II, Theories of Meaning, surveys the competing theories of linguistic meaning and compares their various advantages and liabilities. Part III, Pragmatics and (...) Speech Acts, introduces the basic concepts of linguistic pragmatics, includes a detailed discussion of the problem of indirect force and surveys approaches to metaphor. Unique features of the text: * chapter overviews and summaries * clear supportive examples * study questions * annotated further reading * glossary. (shrink)

In this book William G. Lycan offers an epistemology of philosophy itself, a partial method for philosophical inquiry. The epistemology features three ultimate sources of justified philosophical belief. First, common sense, in a carefully restricted sense of the term-the sorts of contingentpropositions Moore defended against idealists and skeptics. Second, the deliverances of well confirmed science. Third and more fundamentally, intuitions about cases in a carefully specified sense of that term. The first half of On Evidence in Philosophy expounds a (...) version of Moore's method and applies it to each of several issues. This version is shown to resist all the standard objections to Moore; most of them do not even apply. It is argued, in Chapters 5 and 6, that philosophical method is far lesspowerful than most have taken it to be. In particular, deductive argument can accomplish very little, and hardly ever is an opposing position refuted except by common sense or by science. The final two chapters defend the evidential status of intuitions and the Goodmanian method of reflectiveequilibrium; it is argued that philosophy always and everywhere depends on them. The method is then set within a more general explanatory-coherentist epistemology, which is shown to resist standard forms of skepticism.In sum, William G. Lycan advocates a picture of philosophy as a very wide explanatory reflective equilibrium incorporating common sense, science, and our firmest intuitions on any topic-and nothing more, not ever. (shrink)

MEANING POSTULATES REINSTATED If I am right in agreeing with Cresswell that the "logicarrlexicaT distinction is one of degree rather than one of kind, that in turn impugns the distinction between the official truth-rules that define logical ...

Since Twin Earth was discovered by American philosophical-space explorers in the 1970s, the domain of.

Despite the current resurgence of modest forms of mind–body dualism, traditional Cartesian immaterial-substance dualism has few, if any, defenders. This paper argues that no convincing case has been made against substance dualism, and that standard objections to it can be credibly answered.

Now in its Third Edition, Philosophy of Language: A Contemporary Introduction introduces students to the main issues and theories in twentieth-century philosophy of language, focusing specifically on linguistic phenomena. Author William G. Lycan structures the book into four general parts. Part I, Reference and Referring, includes topics such as Russell's theory of descriptions (and its objections), Donnellan's distinction, problems of anaphora, the description theory of proper names, Searle's cluster theory, and the causal-historical theory. Part II, Theories of Meaning, surveys (...) the competing theories of linguistic meaning and compares their various advantages and liabilities. Part III, Pragmatics and Speech Acts, introduces the basic concepts of linguistic pragmatics and includes a detailed discussion of the problem of indirect force. Part IV, The Expressive and the Figurative, examines various forms of expressive language and what "metaphorical meaning" is and how most listeners readily grasp it. (shrink)

Locke put forward the theory of consciousness as "internal Sense" or "reflection"; Kant made it inner sense, by means of which the mind intuits itself or its inner state." On that theory, consciousness is a perception-like second-order representing of our own psychological states events. The term "consciousness," of course, has many distinct uses.

The idea of representation has been central in discussions of intentionality for many years. But only more recently has it begun playing a wider role in the philosophy of mind, particularly in theories of consciousness. Indeed, there are now multiple representational theories of consciousness, corresponding to different uses of the term "conscious," each attempting to explain the corresponding phenomenon in terms of representation. More cautiously, each theory attempts to explain its target phenomenon in terms of _intentionality_, and assumes that intentionality (...) is representation. (shrink)

Lycan (1985, 1988) defended a “Principle of Credulity”: “Accept at the outset each of those things that seem to be true” (1988, p. 165). Though that takes the form of a rule rather than a thesis, it does not seem very different from Huemer’s (2001, 2006, 2007) doctrine of phenomenal conservatism (PC): “If it seems to S that p , then, in the absence of defeaters, S thereby has at least some degree of justification for believing that p ” (2007, (...) p. 30). My Principle was differently motivated and put to uses different from Huemer’s. In this paper I shall explore some of the differences. (shrink)

Second, there is a form of ampliative inference that has come to be called ‘inference to the best explanation,’ or more briefly ‘explanatory inference.’ Roughly: From the fact that a certain hypothesis would explain the data at hand better than any other available hypothesis, we infer with some degree of confidence that that leading hypothesis is correct. There is no question but that this inference is often performed. Arguably, every human being performs it many times in a day, perhaps without (...) letup. (shrink)

It is widely thought that mind–body substance dualism is implausible at best, though mere “property” dualism is defensible and even flourishing. This paper argues that substance dualism is no less plausible than property dualism and even has two advantages over it.